Drenatrophin PMG® for Dogs by Standard Process: Causes, Care, Support

When I work with dogs who seem run down, stressed, or not bouncing back the way they should, I often look at adrenal health. The adrenal glands play a quiet but powerful role in how a dog handles stress, maintains energy, and supports immune balance. That is where Drenatrophin PMG® by Standard Process can be helpful.

This supplement is designed to support healthy adrenal gland function using Standard Process’s proprietary Protomorphogen technology. It has been used for decades by holistic practitioners and remains one of my go-to options when adrenal support makes sense.

What Is Drenatrophin PMG® by Standard Process?

Drenatrophin PMG® is a whole-food based supplement formulated to support the adrenal glands. The adrenals are small endocrine glands that produce hormones involved in stress response, metabolism, immune regulation, and electrolyte balance.

This product contains bovine adrenal PMG™ extract, which is the bovine equivalent of adrenal tissue, along with supportive minerals. The goal is not to replace hormones but to support the structure and function of the adrenal glands themselves.

What does PMG mean?

PMG stands for Protomorphogen. Protomorphogens are specific cellular extracts derived from healthy animal tissues. They contain naturally occurring nucleotides and peptides that help support the same tissue type in the body.

In simple terms, this technology provides targeted nutritional support for specific organs, in this case the adrenal glands.

A Brief History of Drenatrophin PMG®

Standard Process has been producing whole-food supplements since 1929 and has used Protomorphogen technology for more than 60 years. Drenatrophin PMG® has a long history of clinical use in both human and veterinary care and is available only through Standard Process’s proprietary process.

Key Benefits of Drenatrophin PMG® for Dogs

When adrenal support is appropriate, Drenatrophin PMG® can offer several meaningful benefits.

• Supports healthy adrenal gland function

• Helps dogs cope with physical and emotional stress

• Supports normal energy levels and stamina

• Contributes to immune system balance

• Provides minerals involved in nerve, muscle, and metabolic function

Dogs under chronic stress, whether from illness, aging, environmental changes, or long-term inflammation, may place higher demands on their adrenal glands. This supplement is designed to support those demands gently and nutritionally.

Ingredients in Drenatrophin PMG® and What They Do

Each tablet contains a focused blend of minerals and adrenal-derived support.

Active nutrients per tablet

• Calcium 20 mg
  Supports bone health, muscle contraction, nerve signaling, and cellular communication.

• Sodium 10 mg
  Helps maintain fluid balance, nerve impulses, and muscle function.

Proprietary blend 99 mg

• Magnesium citrate
  A highly absorbable form of magnesium that supports energy production, nerve function, muscle relaxation, and metabolic processes.

• Bovine adrenal PMG™ extract
  A proprietary Protomorphogen extract containing naturally occurring nucleotides and peptides derived from bovine adrenal tissue. This supports adrenal structure and cellular function.

Other ingredients

• Calcium lactate

• Cellulose

• Calcium stearate

These are used for tablet stability and delivery.

How Drenatrophin PMG® Supports Specific Health Concerns in Dogs

This supplement is not a drug and does not force hormonal changes. Instead, it supports normal adrenal function so the body can regulate itself more effectively.

Adrenal stress and fatigue

The adrenal glands help regulate how a dog responds to stress. Chronic stress can come from illness, pain, anxiety, overtraining, or environmental changes. Nutritional adrenal support may help maintain resilience during these periods.

Stress response and behavior changes

Dogs experiencing stress may show changes in energy, appetite, digestion, or behavior. Supporting adrenal health can help the body manage stress more efficiently.

Immune system balance

Adrenal hormones influence immune regulation. Supporting healthy adrenal function can indirectly support balanced immune responses, especially in dogs under long-term stress.

How Protomorphogen Technology Works

Protomorphogen extracts contain tissue-specific nucleotides and peptides. These compounds are believed to help support cellular communication and tissue integrity.

In Drenatrophin PMG®, the adrenal-derived extract supports the adrenal glands at a structural and cellular level rather than acting as a stimulant or hormone replacement.

Dosage and Administration for Dogs

Always work with your veterinarian to determine the best dose for your dog.

General dosing guidelines

Small dogs 1 to 20 lbs
2 tablets daily

Medium dogs 21 to 50 lbs
3 tablets daily

Large dogs over 51 lbs
4 tablets daily

How to give Drenatrophin PMG®

• Best given on an empty stomach when possible

• Tablets may be given directly or hidden in a small amount of food

• Consistency matters more than timing, so aim for the same schedule each day

Possible Side Effects and Safety Considerations

Drenatrophin PMG® is generally well tolerated. Mild digestive changes such as soft stool or constipation can occur in some dogs as they adjust.

Less commonly, dogs may appear temporarily tired. If symptoms persist, stop the supplement and consult your veterinarian.

Do not use without veterinary guidance if your dog has endocrine disease, is pregnant, or is taking prescription medications that affect adrenal or hormonal function.

Supplements are meant to complement a balanced diet, not replace proper nutrition or veterinary care.

Final Thoughts from Dr. Candy

When used thoughtfully, Drenatrophin PMG® can be a valuable tool for supporting adrenal health, stress resilience, and overall balance in dogs. I appreciate this product because it works with the body rather than pushing it.

If your dog seems chronically stressed, fatigued, or slow to recover, adrenal support may be worth exploring with your veterinarian.

Frequently Asked Questions

What is Drenatrophin PMG® for dogs?
Drenatrophin PMG® is a whole-food supplement designed to support healthy adrenal gland function and stress response in dogs using bovine adrenal Protomorphogen extracts.

How does Drenatrophin PMG® work?
It provides a unique profile of adrenal-derived nucleotides and peptides along with supportive minerals that help maintain adrenal structure and function.

Is Drenatrophin PMG® a hormone?
No. It does not contain hormones and does not replace adrenal hormones. It supports the adrenal glands nutritionally.

Can Drenatrophin PMG® be used with other supplements?
In many cases yes, but it should always be discussed with your veterinarian, especially if your dog is on medications or other glandular products.

How long does it take to see results?
Response time varies. Some dogs show improvement within a few weeks, while others may need longer periods of consistent support.