What Is the Difference Between Ligaplex I and Ligaplex II?

By Dr. Candy Akers

Ligaplex I and II are two different nutritional supplements that were designed by Standard Process. Standard Process makes some of the most effective nutritional supplements on the market. Healthcare practitioners have been usin Ligaplex I and Ligaplex II for over 60 years.  

The following information is a summary and review based on Dr. Candy’s professional experience and recommendations. Any summary or statement has not been provided nor influenced by the manufacturer.

Both of these formulations are designed to support the musculoskeletal system. Ingredients can help to heal bones, cartilage, tendons and ligaments. 

Ligaplex I and II share a lot of the same ingredients. This could make chasing the correct supplement confusing. I’m going to show how these supplements are different and which one you should take for your health goal.  

The primary difference between Ligaplex I and Ligaplex II is that Ligaplex I is better suited to help heal acute or short term injuries. Ligaplex II is better for long term or chronic support of the musculoskeletal system. 

The primary difference between Ligaplex I and Ligaplex IIis that Ligaplex I is better suited to help heal acute or short term injuries. Ligaplex II is better for long term or chronic support of the musculoskeletal system. 

Ligaplex I has higher amounts of vitamin E, manganese and vitamin B12. These nutrients are needed in larger quantities when a lot of inflammation is present. For example, like right after an injury or surgery. This phase of healing involves a lot of swelling around the injury location and a significant amount of pain. 

Chronic or long term recovery typically has less obious swellin and less pain. However, these long term or past injuries need nutrients such as vitamin A, a fat soluable vitamin that is depleted from the body during long term healing. 

In practice, I useLigaplex Ifor injuries less than 8 weeks old andLigaplex IIfor the healing support of injuries older than 8 weeks. 

Check out these pages for more specific details about the individual products: 

Additional Information for Ligaplex I:

Additional Information for Ligaplex II:

Dr. Candy’s Pro-Tip:What’s the deal with manganese? Over the past few years we have heard a lot about emerging scientific research that ties manganese deficiency to injuries of ligaments and joints. The evidence shows that modern day deficiencies of this mineral are significantly contributing to injuries of athletes, kids, and even dogs. Most of our soils are now critically low in essential minerals like manganese, zinc and copper. Industrial farming and agriculture strip the land of nutrients. This can be caused by growing the same crop over and over - as well as herbicide chemicals like glyphosate which binds those minerals in unusable compounds. 

Why Do We Need Manganese for Healthy Joints? 

Manganese is an important nutrient for joint health. This mineral helps remove tissue inflammation after work or injury. Manganese also contributes to a calm demeanor and helps patients remain calm. Just a small increase in calmness can possibly prevent the effects of the wind up pain. Manganese is also needed for manufacturing cartilage and bone. Its is required for the formation of collagen too. Collagen is the tissue that builds strong ligaments and joints. 

Ligaplex ILigaplex II
PurposeBetter for acute / short term injury recoveryBetter for long term support, maintenance and chronic disease
InflammationInjury with a great amount of swelling / inflammationLower inflammation environment
Vitamin EMore vitamin E - which stimulates cartilage growthHigher in vitamin A - helps to reduce inflammation and fulfill replenishment of critically important fat-soluble vitamins
Vitamin ALower in vitamin AHigher in vitamin A - helps to reduce inflammation and fulfill replenishment of critically important fat-soluble vitamins
ManganeseMore manganese (55mg) - reduced pain sensation, required to build collagen and ligamentsManganese (35mg) for repair of bones, cartilage, collagen, tendons and ligaments
Vitamin B12Vitamin B12 (5.8mcg) - helps form healthy bone, reduce inflammation and reduce the perception of painVitamin B12 (2mcg) - improves health and density of bones
Resource: manganese article from Oregon State - include link - source saved as “manganese Article Oregon” https://lpi.oregonstate.edu/mic/minerals/manganese

Customers Also Bought:

author image

Dr. Candy Akers

About the Author

Holistic Veterinarian, Veterinary Clinic Owner, Veterinary Medical Supervisory Board Leader, Certified Raw Dog Food Nutrition Specialist, and Author Dr. Candy completed her undergraduate studies at The University of Delaware and graduated veterinary school in 2009 from Oklahoma State University. In high school, she was drawn to wildlife rehabilitation. Wildlife rehab gave her unparalleled experience in animal healing in a field that has limited resources and a wide variety of conditions to treat. Before vet school, Dr. Akers spent two years working full time providing oil spill response for wildlife all over the country. Since graduating with her Degree of Veterinary Medicine (DVM) in 2009, Dr. Candy has specialized in companion animal nutrition. Extensive education in nutrition has made her a firm believer in species specific-biologically appropriate diets. One of her passions is educating pet parents about the natural alternatives that actually work. She brings the best of holistic health and conventional medicine together in a unique approach to pet health. This approach is often applied to chronic diseases, allergies, and autoimmune conditions. She started her own veterinary practice 9 years ago in Colorado. Overall, she has dedicated her entire life to improving the health and happiness of animals everywhere.